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CEM Corporation microwave synthesizer cem 2.0 discover
Microwave Synthesizer Cem 2.0 Discover, supplied by CEM Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microwave+synthesizer+cem+discover%C2%AE+2%2E0/microwave+synthesizer+cem+discover/pmc12018053-80-0-6
Average 90 stars, based on 1 article reviews
microwave synthesizer cem 2.0 discover - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles
Article Snippet: Column chromatography: Column chromatography was carried out with silica gel grade 60 (0.040–0.063 mm) 230–400 mesh using Biotage Isolera Prime instrument.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Preparation of dimethyl 5,7-dibenzyl-6,8-dioxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5e][1,3,5]triazepine-2,3-dicarboxylate (14) N N Bn OO N2Bn N N Bn OO Bn N N MeO2C CO2Me DMAD PhH, 60 oC (MW) N N MeO2C CO2Me N N O O Bn Bn1,5 h 14, 70%3i The solution of 1,3-dibenzyl-5-diazodihydropyrimidine-2,4(1H,3H)-dione 3i (235 mg, 0.73 mmol, 1.0 equiv.) and dimethyl acetylenedicarboxylate (142 mg, 1.00 mmol, 1.36 equiv.) in toluene (3 mL) was irradiated at 60°C in a Microwave Synthesizer CEM Discover® 2.0 at 1.5 h. After completion of the reaction, the mixture was evaporated at a rotary evaporator under reduced pressure and the residue was purified by recrystallisation from hexane-acetone mixture.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (automatic temperature control by internal sensor, standard mode – irradiating the sample with the highest available power for the shortest period of time).

Article Title: Access to Spiro Bis-β-lactams via a Metal-Free Microwave-Assisted Wolff Rearrangement/Staudinger [2+2] Cycloaddition Cascade Involving 3-Diazotetramic Acids and Imines
Article Snippet: Microwave Reactor: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (Standard mode – irradiating the sample with the highest available power for the shortest period of time).

Irradiation:

Article Title: Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles
Article Snippet: Column chromatography: Column chromatography was carried out with silica gel grade 60 (0.040–0.063 mm) 230–400 mesh using Biotage Isolera Prime instrument.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Preparation of dimethyl 5,7-dibenzyl-6,8-dioxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5e][1,3,5]triazepine-2,3-dicarboxylate (14) N N Bn OO N2Bn N N Bn OO Bn N N MeO2C CO2Me DMAD PhH, 60 oC (MW) N N MeO2C CO2Me N N O O Bn Bn1,5 h 14, 70%3i The solution of 1,3-dibenzyl-5-diazodihydropyrimidine-2,4(1H,3H)-dione 3i (235 mg, 0.73 mmol, 1.0 equiv.) and dimethyl acetylenedicarboxylate (142 mg, 1.00 mmol, 1.36 equiv.) in toluene (3 mL) was irradiated at 60°C in a Microwave Synthesizer CEM Discover® 2.0 at 1.5 h. After completion of the reaction, the mixture was evaporated at a rotary evaporator under reduced pressure and the residue was purified by recrystallisation from hexane-acetone mixture.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (automatic temperature control by internal sensor, standard mode – irradiating the sample with the highest available power for the shortest period of time).

Article Title: Access to Spiro Bis-β-lactams via a Metal-Free Microwave-Assisted Wolff Rearrangement/Staudinger [2+2] Cycloaddition Cascade Involving 3-Diazotetramic Acids and Imines
Article Snippet: Microwave Reactor: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (Standard mode – irradiating the sample with the highest available power for the shortest period of time).

Residue:

Article Title: Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles
Article Snippet: Column chromatography: Column chromatography was carried out with silica gel grade 60 (0.040–0.063 mm) 230–400 mesh using Biotage Isolera Prime instrument.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Preparation of dimethyl 5,7-dibenzyl-6,8-dioxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5e][1,3,5]triazepine-2,3-dicarboxylate (14) N N Bn OO N2Bn N N Bn OO Bn N N MeO2C CO2Me DMAD PhH, 60 oC (MW) N N MeO2C CO2Me N N O O Bn Bn1,5 h 14, 70%3i The solution of 1,3-dibenzyl-5-diazodihydropyrimidine-2,4(1H,3H)-dione 3i (235 mg, 0.73 mmol, 1.0 equiv.) and dimethyl acetylenedicarboxylate (142 mg, 1.00 mmol, 1.36 equiv.) in toluene (3 mL) was irradiated at 60°C in a Microwave Synthesizer CEM Discover® 2.0 at 1.5 h. After completion of the reaction, the mixture was evaporated at a rotary evaporator under reduced pressure and the residue was purified by recrystallisation from hexane-acetone mixture.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (automatic temperature control by internal sensor, standard mode – irradiating the sample with the highest available power for the shortest period of time).

Article Title: Access to Spiro Bis-β-lactams via a Metal-Free Microwave-Assisted Wolff Rearrangement/Staudinger [2+2] Cycloaddition Cascade Involving 3-Diazotetramic Acids and Imines
Article Snippet: Microwave Reactor: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (Standard mode – irradiating the sample with the highest available power for the shortest period of time).

Purification:

Article Title: Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles
Article Snippet: Column chromatography: Column chromatography was carried out with silica gel grade 60 (0.040–0.063 mm) 230–400 mesh using Biotage Isolera Prime instrument.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Preparation of dimethyl 5,7-dibenzyl-6,8-dioxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5e][1,3,5]triazepine-2,3-dicarboxylate (14) N N Bn OO N2Bn N N Bn OO Bn N N MeO2C CO2Me DMAD PhH, 60 oC (MW) N N MeO2C CO2Me N N O O Bn Bn1,5 h 14, 70%3i The solution of 1,3-dibenzyl-5-diazodihydropyrimidine-2,4(1H,3H)-dione 3i (235 mg, 0.73 mmol, 1.0 equiv.) and dimethyl acetylenedicarboxylate (142 mg, 1.00 mmol, 1.36 equiv.) in toluene (3 mL) was irradiated at 60°C in a Microwave Synthesizer CEM Discover® 2.0 at 1.5 h. After completion of the reaction, the mixture was evaporated at a rotary evaporator under reduced pressure and the residue was purified by recrystallisation from hexane-acetone mixture.

Article Title: 5-Diazo Dihydrouracils: Preparation and Some Transformations.
Article Snippet: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (automatic temperature control by internal sensor, standard mode – irradiating the sample with the highest available power for the shortest period of time).

Article Title: Access to Spiro Bis-β-lactams via a Metal-Free Microwave-Assisted Wolff Rearrangement/Staudinger [2+2] Cycloaddition Cascade Involving 3-Diazotetramic Acids and Imines
Article Snippet: Microwave Reactor: Microwave-assisted reactions were performed using Microwave Synthesizer CEM Discover® 2.0 (Standard mode – irradiating the sample with the highest available power for the shortest period of time).



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